Low Histamine Depression

If you go here: http://www.livingnetwork.co.za/chelationnetwork/depression/ and read about different reasons for depression, you might find some answers.

Or, you might become confused.

I’m pretty sure #4 is my issue:

4). No motivation, no energy, don’t enjoy anything, sit around like a bump on a log, unaroused, unaware, but mood OK (you don’t feel DEPRESSED, you just don’t feel much at all) = Low histamine depression.

But the solution to that has been confusing the heck out of me:

4). If you have low histamine depression, IF YOU ARE NOT ALLERGIC AND HAVE NO INFLAMMATORY PROBLEM, try l-histidine 1-3 grams a day. If you are allergic this will make your allergies dramatically worse and you must NOT do it. In that case, take a lot of nonsedating antihistamines and other allergy medications, for example Allegra (fexofenadine) and Singulair or Accolate and Nasalchrom as this may let your body tolerate more histamine. AVOID all medications that have antihistaminic side effects and all antihistamines that get into the brain (which is all the over the counter ones).

The “you must NOT do it” sounds dire.

Since I am full of inflammation from mercury, I should avoid that stuff like crazy, right?

But looking up Allegra, I see all kinds of people online saying how Allegra made them feel suicidally depressed.

I don’t need THAT either.

So I finally asked the source. Andy Cutler.

I had it wrong. It’s take the l-histidine, but if you have allergies or inflammation, then be cautious, and be prepared to take the antihistamines so that you can tolerate the l-histidine. It’s not an either or, it’s an either, or both.

So. Something to try.

Wish me luck.


More: It’s not easy to find info about low histamine. Lots of info about high histamine, histamine intolerance, low histamine diets, etc. But not much about low histamine.

Here is one scientific study that says low histamine levels are associated with sleepiness. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635574/

Here is one that gives some causes for low histamine:

Factors [1] that can reduce your brain histamine levels include:

  • ongoing deficiencies in zinc, vitamin C, folic acid and niacin (vitamin B3)
  • excessive blood copper (which allows excessive histamine degradation to take place)
  • long term use of drugs like Dilantin (an antiepileptic), which destroys the body’s supply of folic acid and can bring about severe paranoia and low histamine levels
  • increased estrogen levels due to the use of birth control pills or during pregnancy can lead to elevated copper levels, which can in turn bring about low histamine levels.
  • According to Joan Mathew Larson, Ph.D. (nutrition), founder and executive director of the highly esteemed Health Recovery Centre (HRC) in Minneapolis, Minnesota, people with Type A blood type may be more prone to sequestering copper and subsequently, have lower histamine levels.

The above maybe makes sense, as I’m typically always low in zinc, C, folic acid and b’s. I’m not sure about the copper, as my copper was low on my hair test. I do have estrogen dominance issues and have for years. And I have type A blood.


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